Hyperlipidemia produced by serum lipoprotein abnormalities or lipoprotein receptor mutations.

Activation of lipoprotein lipase by lipoprotein fractions of human serum.

Triglycerides in fat emulsions are hydrolyzed by lipoprotein lipase only when they are "activated" by serum lipoproteins. The contribution of different lipoprotein fractions to hydrolysis of triglycerides in soybean oil emulsion was assessed by determining the quantity of lipoprotein fraction required to give half-maximal hydrolysis. Most of the activator property of whole serum from normolipid...

High density Lipoprotein; What to Measure: Quality or Quantity?

Lipoprotein compositional abnormalities and insulin resistance in type II diabetic patients with mild hyperlipidemia.

Lipoprotein composition was determined using ultracentrifugation in 20 non-insulin-dependent (NIDDM) diabetic patients on diet only (D), 20 NIDDM patients on diet and sulfonylurea therapy (T), and 20 nondiabetic control subjects (C), all of whom had total plasma cholesterol concentrations < 6.5 mmol/L and total plasma triglyceride concentrations < 3.0 mmol/L. Although the groups were well match...

Lipoprotein Patterns of Serum Obtained by Zone

For a number of years the lipoproteins of serum have been classified as alpha and beta types according to their electrophoretic mobility. Despite this designation very few studies of their electrophoretic properties have been reported. This is chiefly due to the fact that it is very difficult to determine exactly where the lipoproteins migrate when patterns of whole serum are obtained by the cl...

Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype.

OBJECTIVE The present study addresses the presence of distinct metabolic phenotypes in familial combined hyperlipidemia (FCHL) in relation to small dense low-density lipoprotein (sd LDL) and very low-density lipoprotein (VLDL) subclasses. METHODS AND RESULTS Hyperlipidemic FCHL relatives (n=72) were analyzed for LDL size by gradient gel electrophoresis. Pattern B LDL (sd LDL, particle size <2...